Publications by authors named "T Plante-Bordeneuve"
Post-capillary hypertension resulting from mitral regurgitation is typically considered a contraindication for single lung transplantation due to heightened risks of primary graft dysfunction. This case report highlights a 66-year-old COPD patient with severe mitral regurgitation who was deemed ineligible for surgical mitral replacement. As an alternative, transcatheter mitral valve replacement was successfully performed, resulting in the normalization of pulmonary artery pressures.
View Article and Find Full Text PDFBackground: The airway epithelium (AE) fulfils multiple functions to maintain pulmonary homeostasis, among which ensuring adequate barrier function, cell differentiation and polarization, and actively transporting immunoglobulin A (IgA), the predominant mucosal immunoglobulin in the airway lumen, via the polymeric immunoglobulin receptor (pIgR). Morphological changes of the airways have been reported in ARDS, while their detailed features, impact for mucosal immunity, and causative mechanisms remain unclear. Therefore, this study aimed to assess epithelial alterations in the distal airways of patients with ARDS.
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- Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome that can occur in individuals with genetic predispositions or in immunocompromised patients, though it’s particularly rare in solid organ transplant recipients, such as lung transplant patients.
- This case study presents an unusual incident of HLH developing 11 years after lung transplantation in a 67-year-old patient, with symptoms including pancytopenia, fever, and splenomegaly, and showed signs of post-transplant lymphoproliferative disorder (PTLD).
- Despite treatment with etoposide, corticosteroids, and rituximab, the patient ultimately died from complications, highlighting the need for
Chronic obstructive pulmonary disease (COPD), a devastating and irreversible lung disease, causes structural and functional defects in the bronchial epithelium, the (ir)reversibility of which remains unexplored in vitro. This study aimed to investigate the persistence of COPD-related epithelial defects in long-term airway epithelial cultures derived from non-smokers, smokers, and COPD patients. Barrier function, polarity, cell commitment, epithelial-to-mesenchymal transition, and inflammation were evaluated and compared with native epithelium characteristics.
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