Publications by authors named "T Phu"
The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment. Employing the KPC mouse model of pancreatic cancer, we demonstrate that pancreatic epithelial nSMase2 ablation reduces neoplasia and promotes a PDA subtype switch from aggressive basal-like to classical.
View Article and Find Full Text PDFArticle Synopsis
- Exosomes are small membrane-bound vesicles playing key roles in various biological processes, and an innovative transgenic mouse model called Exomap1 was developed to study their biology.
- The Exomap1 mouse expresses a fluorescent exosome marker (HsCD81mNG) specifically when induced by Cre recombinase, allowing for tracking and analysis of exosome secretion and composition.
- Findings showed distinct contributions from different cell types to exosome populations, with neurons contributing ~1% and hepatocytes ~15% to plasma exosomes, affirming the model's utility for exosome research.
Article Synopsis
- Current heart failure treatments following myocardial infarction (MI) are insufficient, highlighting a gap in cardiovascular care.
- This study explores exosomes from human macrophages treated with the cytokine IL-4 (THP1-IL4-exo), which help improve heart function in mice with MI due to diet-induced coronary artery disease.
- THP1-IL4-exo works by reprogramming specific immune cells and reducing inflammation, ultimately preventing heart damage and preserving heart function after an MI.*
Clinical effectiveness of genetic testing guidelines in patients with thoracic aortic aneurysms.
J Thorac Cardiovasc Surg
September 2024
Objective: To analyze the effectiveness of the current genetic testing guidelines for patients with thoracic aortic aneurysms.
Methods: We evaluated genetic tests for thoracic aortic disease (TAD) from 2012 to 2023 in patients aged 18 and older with a thoracic aorta diameter greater than 4 cm. Mutation rates were compared by American College of Cardiology/American Heart Association testing criteria met by patients: age younger than 60 years, syndromic features of connective tissue diseases (CTDs), family history, or none.
Electrochemical CO reduction reaction (CORR) to produce value-added multi-carbon chemicals has been an appealing approach to achieving environmentally friendly carbon neutrality in recent years. Despite extensive research focusing on the use of CO to produce high-value chemicals like high-energy-density hydrocarbons, there have been few reports on the production of propane (CH), which requires carbon chain elongation and protonation. A rationally designed 0D/2D hybrid CuO anchored-TiCT MXene catalyst (CuO/MXene) is demonstrated with efficient CORR activity in an aqueous electrolyte to produce CH.
View Article and Find Full Text PDF