Publications by authors named "T Philippe"
Background: The choroid plexus (ChP) is formed by epithelial cells and stromal fibroblasts which act as a blood-cerebrospinal fluid (CSF) barrier, play a key role in maintaining brain homeostasis, and provide a niche for immune cells. ChP dysfunction has been implicated in Alzheimer's Disease (AD), including changes in CSF secretion, increased apoptosis, and dysregulated immune, mitochondrial, and transporter functions.
Method: Here, we performed single-nuclei RNA-Sequencing (snRNA-Seq) on 965,647 ChP nuclei from 68 ROSMAP participants with no cognitive impairment (NCI), mild cognitive impairment (MCI) or Alzheimer's Dementia (ADem).
Article Synopsis
- - A new phase-field model is developed to study surface diffusion in crystals with uneven surface energy, showing it can simplify to a sharp-interface equation when the interface width is very small.
- - The model reveals that when a metastable crystal surface evolves, the process of nucleation and growth can create new surface domains that lead to a more structured hill-and-valley shape, differing from the random patterns seen in typical thermal nucleation.
- - The study also finds specific growth patterns during coarsening, including a characteristic length scale that grows over time following a scaling law and a junction density that decreases in a predictable manner, highlighting how induced nucleation affects phase separation in crystals.
Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and 2-fold higher plasma corticosterone levels in females. Glucocorticoids control hepatic development and metabolic activities, and we have therefore examined how disrupting the SerpinA6 gene encoding CBG influences plasma corticosterone dynamics, as well as liver gene expression in male and female rats before and after puberty.
View Article and Find Full Text PDFThe kinetic equation for anisotropic motion-by-curvature is ill posed when the surface energy is strongly anisotropic. In this case, corners or edges are present on the Wulff shape, which span a range of missing orientations. In the sharp-interface problem the surface energy is augmented with a curvature-dependent term that rounds the corners and regularizes the dynamic equations.
View Article and Find Full Text PDFEncoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal to adult transition using CRISPR/cas9 to disrupt SerpinA6 gene expression. In the absence of CBG, total plasma corticosterone levels were ∼80% lower in adult rats of both sexes, with a greater absolute reduction in females than in males.
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