Publications by authors named "T Pham Van"
Background: Multi-cancer early detection (MCED) through a single blood test significantly advances cancer diagnosis. However, most MCED tests rely on a single type of biomarkers, leading to limited sensitivity, particularly for early-stage cancers. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles to detect five common cancers.
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- The study investigates how gut microbial metabolites (GMM), specifically phenylacetylglutamine (PAGln), are linked to cardiovascular diseases (CVD) in people with alcohol use disorder.
- In experiments with mice, researchers found that chronic alcohol consumption led to changes in gut microbes and increased PAGln levels, which were associated with cardiovascular issues.
- PAGln was shown to cause heart and blood vessel problems independent of alcohol, indicating that it plays a significant role in the development of CVD related to alcohol consumption.
Extracellular vesicles (EVs), crucial mediators in cell-to-cell communication, are implicated in both homeostatic and pathological processes. Their detectability in easily accessible peripheral fluids like saliva positions them as promising candidates for non-invasive biomarker discovery. However, the lack of standardized methods for salivary EVs isolation greatly limits our ability to study them.
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- Halong Bay in northern Vietnam is experiencing significant environmental impact from human activities, specifically from metals and metalloids used as indicators for tracing anthropogenic contributions.
- Two sediment cores, one from coastal waters and another from a small isolated lake, revealed that the coastal site (HL) had a much higher accumulation rate than the lake site (HT).
- Key findings indicate that the coastal waters are heavily influenced by the Red River drainage, with particular historical pollution spikes linked to significant events like the Indochina War and various regional flooding incidents.
Background: Research on evaluating the efficacy of non-cultured epidermal cell suspension (NCECS) combined with excimer lamps for the treatment of vitiligo is currently unavailable. This research aims to evaluate the efficacy of this combination in treating vitiligo.
Methods: A prospective, controlled study was conducted from November 2021 to January 2024.