Publications by authors named "T Pfister"
Background: The majority of patients with alcohol use disorder (AUD) regularly take medication. Alcohol interacts negatively with many commonly prescribed drugs. However, little is known about the characteristics and frequency of potential alcohol-medication and drug-drug interactions in patients with AUD.
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- Permitted Daily Exposure Limits (PDEs) for Active Pharmaceutical Ingredients (APIs) are crucial for managing cross-contamination in shared manufacturing facilities, but companies must set their own limits due to the absence of official lists.
- Despite the existence of general guidelines, variations in PDE settings among companies are acceptable within a defined range.
- A study comparing PDEs for five marketed APIs demonstrated that the variations are generally minor (under 10-fold), with notable differences primarily for morphine, highlighting factors such as data availability and company policies that influence these limits.
Drug safety in older patients with alcohol use disorder: a retrospective cohort study.
Ther Adv Psychopharmacol
February 2024
Background: Older patients with alcohol use disorder are at particular risk of developing adverse drug reactions due to multimorbidity, polypharmacy, and altered organ function.
Objectives: In this study, we investigated the frequency and characteristics of potentially serious alcohol-medication interactions, potentially inappropriate medications (PIMs) for older adults, and potential drug-drug interactions (pDDIs) in a population of older patients with alcohol use disorder over a 10-year period.
Design: Retrospective monocentric cohort study.
Introduction: Older patients are frequently affected by infectious diseases and adverse drug reactions (ADRs) of consecutively prescribed antibiotics. Particularly within geriatric psychiatry, high rates of potentially inappropriate prescriptions (PIPs) have been described, significantly complicating pharmacological treatment. Therefore, this study aimed to investigate the frequency and characteristics of antibiotic PIPs in geriatric psychiatry.
View Article and Find Full Text PDFBackground: Developments in the field of digital measures and digitally derived endpoints demand greater attention on globally aligned approaches to enhance digital measure acceptance by regulatory authorities and health technology assessment (HTA) bodies for decision-making. In order to maximize the value of digital measures in global drug development programs and to ensure study teams and regulators are referring to the same items, greater alignment of concepts, definitions, and terminology is required. This is a fast-moving complex field; every day brings new technologies, algorithms, and possibilities.
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