Publications by authors named "T Petitjean"
Given its relevance across numerous fields, reductive amination is one of the oldest and most widely used methods for amine synthesis. As a cornerstone of synthetic chemistry, it has largely remained unchanged since its discovery over a century ago. Herein, we report the mechanistically driven development of a complementary reaction, which reductively aminates the C-C σ-bond of carbonyls, not the carbonyl C-O π-bond, generating value-added linear and cyclic 3° amines in a modular fashion.
View Article and Find Full Text PDFBackground And Objectives: Sleepiness in patients with obstructive sleep apnea (OSA) is associated with accidental and economic burden, as well as cardiovascular risk. Despite OSA treatment, 10-28 % of patients report residual sleepiness. Its determinants, as well as those of objective impaired alertness remain poorly known.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create and validate a natural language processing (NLP) pipeline capable of identifying 18 medical conditions in French clinical notes, including various comorbidities from the Charlson index, while ensuring privacy in a collaborative research environment.
- The detection pipeline employed both rule-based and machine learning techniques, utilizing a large language model and annotated clinical notes from three research studies focused on oncology, cardiology, and rheumatology.
- Results showed high accuracy metrics, including a macro-averaged F1-score of 95.7, indicating that the collaborative effort significantly outperformed other methods, demonstrating the effectiveness of secure teamwork in developing advanced medical AI models.
Objective: Sudden and unexpected deaths in epilepsy (SUDEP) pathophysiology may involve an interaction between respiratory dysfunction and sleep/wake state regulation. We investigated whether patients with epilepsy exhibit impaired sleep apnea-related arousals.
Methods: Patients with drug-resistant (N = 20) or drug-sensitive (N = 20) epilepsy and obstructive sleep apnea, as well as patients with sleep apnea but without epilepsy (controls, N = 20) were included.