Publications by authors named "T Perez Concha"
Article Synopsis
- Fluoxetine is a popular selective serotonin reuptake inhibitor (SSRI) used mainly for treating major depressive disorder and other central nervous system conditions due to its safety and effectiveness.
- The drug's antidepressant effects are well-understood, involving serotonin reuptake inhibition and activation of key brain receptors related to neurotrophic support.
- However, the impact of fluoxetine on cognitive functions is mixed, with some studies showing improvements in patients while others reveal negative effects influenced by factors like gender, age, and treatment duration, highlighting the need for cautious prescribing and more research.
Myocardial MIBG scintigraphy in genetic Parkinson's disease as a model for Lewy body disorders.
Eur J Nucl Med Mol Imaging
February 2019
Purpose: To identify myocardial sympathetic denervation patterns suggestive of Lewy body (LB) pathology in patients with genetic and idiopathic parkinsonisms by I-metaiodobenzylguanidine (MIBG) scintigraphy.
Methods: We retrospectively analysed myocardial MIBG images acquired with a dual-head gamma camera and low-energy high-resolution collimator (LEHR) in 194 patients with suspected synucleinopathy or atypical parkinsonism, including 34 with genetic Parkinson's disease (PD; 4 PARK1, 8 PARK2 and 22 PARK8), 85 with idiopathic PD (iPD), 6 with idiopathic REM sleep behaviour disorder (iRBD), 17 with dementia with LB (DLB), 40 with multiple system atrophy (MSA) and 12 with progressive supranuclear palsy (PSP), and in 45 healthy controls. We calculated heart-to-mediastinum MIBG uptake ratios (HMR) at 15 min and 4 h (HMR4H) for the LEHR and standardized medium-energy collimators, to obtain classification accuracies and optimal cut-off values for HMR using supervised classification and ROC analyses.