Publications by authors named "T Pena"

Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this decline, the mechanisms are not fully understood. Long non-coding RNAs (lncRNAs) are key regulators of cellular functions.

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Although the prognosis of breast cancer has significantly improved compared to other types of cancer, there are still some patients who expire due to recurrence or metastasis. Therefore, it is necessary to develop a method to identify patients with poor prognosis at the early stages of cancer. In the process of discovering new prognostic markers from genes of unknown function, we found that the expression of C1orf50 determines the prognosis of breast cancer patients, especially for those with Luminal A breast cancer.

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Plants have developed various strategies to deal with abiotic stresses throughout their lifetimes. However, environmental stresses can have long-lasting effects, positively modifying plant physiological responses to subsequent stress episodes, a phenomenon known as preconditioning or stress memory. Intriguingly, this memory can even be transmitted to offspring, referred to as "inter- or transgenerational memory".

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Article Synopsis
  • Delineating species in microorganisms is difficult due to limited markers; this study used an integrative taxonomy approach that combines genomic analysis, phenotypic profiling, and reproductive isolation assessments.
  • The research identified a new species, Saccharomyces chiloensis sp. nov., in coastal Patagonia, which is genetically distinct from its sister species S. uvarum, showing 7% genetic divergence and evidence of reproductive isolation.
  • The findings highlight the unique biodiversity of Patagonia and the need for comprehensive methods in taxonomy to discover previously unrecognized microbial species, emphasizing the evolutionary divergence resulting from glaciation and geographic separation.
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