ChatGPT vs. surgeons on pancreatic cancer queries: accuracy & empathy evaluated by patients and experts.

Background: Artificial intelligence (AI) offers potential support in patient-clinician interactions, but its impact on such communication remains unexplored.

Methods: In this study, ChatGPT was compared with two pancreatic surgeons in responding to ten pancreatic cancer surgery-related questions, co-designed with the Patient Advisory Board of the Surgical Society's Study Center. A blind evaluation of these responses, considering content congruency and clarity for non-specialists, was conducted by patients and surgeons.

Fluorinated non-fluorinated tetrahedral TriTri porous organic cages for H, CO, and CH adsorption.

We present the synthesis of two porous complementary tetrahedral TriTri imine cages, exhibiting Brunauer-Emmett-Teller (BET) surface areas of 591 m g and 753 m g, suitable for the adsorption of H, CO, and CH. Comparisons in terms of crystallinity, thermal stability, porosity, and selectivity highlight the promising properties of fluorinated and non-fluorinated porous organic cages as functional materials.

Fluorinated Squareimines for Molecular Sieving of Aromatic over Aliphatic Compounds.

The development of more energy-efficient separation technologies is essential. Especially the separation of cyclic aliphatic hydrocarbons from their aromatic counterparts remains a significant challenge due to azeotrope formation and similar physical properties, often requiring energy-intensive processes. Herein, we introduce a novel class of electron-deficient macrocycles with a unique rectangular structure to optimise interactions within the pore, enabling the highly selective molecular sieving of aromatic compounds from mixtures.

Multifold Post-Modification of Macrocycles and Cages by Isocyanate-Induced Azadefluorination Cyclisation.

We present the multiple post-modification of organic macrocycles and cages, introducing functional groups into two- and three-dimensional supramolecular scaffolds bearing fluorine substituents, which opens up new possibilities in multi-step supramolecular chemistry employing the vast chemical space of readily available isocyanates. The mechanism and scope of the reaction that proceeds after isocyanate addition to the benzylamine motif via an azadefluorination cyclisation (ADFC) were investigated using DFT calculations, and a series of aromatic isocyanates with different electronic properties were tested. The compounds show excellent chemical stability and were fully characterised.