Publications by authors named "T Paajanen"
Background And Purpose: Executive dysfunction and slowed processing speed are central cognitive impairments in cerebral small vessel disease (cSVD). It is unclear whether the subcomponents of executive functions become equally affected and whether computerized tests are more sensitive in detecting early cognitive changes over traditional tests. The associations of specific executive abilities (cognitive flexibility, inhibitory control, working memory) and processing speed with white matter hyperintensities (WMHs) and Instrumental Activities of Daily Living (IADL) were examined.
View Article and Find Full Text PDFSubjective Memory Complaints and the Effect of a Multidomain Lifestyle Intervention on Cognition: The FINGER Trial.
J Gerontol B Psychol Sci Soc Sci
December 2024
Article Synopsis
- - The study investigates how subjective memory complaints (SMCs) affect the effectiveness of a 2-year multidomain lifestyle intervention focused on preventing cognitive decline in older adults.
- - Participants aged 60-77 were divided into two groups: one receiving an intervention involving diet, exercise, and cognitive training, and another receiving regular health advice, with cognitive performance tested before and after the intervention.
- - Results indicated that individuals with more SMCs showed a greater improvement in memory performance from the intervention, suggesting that such lifestyle changes may be particularly beneficial for those experiencing these complaints.
Article Synopsis
- The study tackles the challenges of understanding major depressive disorder (MDD) by examining multimorbidities to identify specific subtypes influenced by genetic and non-genetic factors.
- The researchers analyzed data from 1.2 million individuals across the UK, Finland, and Spain, using dynamic Bayesian network approaches to discover seven distinct clusters of disease burdens linked to MDD.
- Findings highlight the importance of inflammatory processes and suggest that personalized treatments for MDD could be developed based on the unique profiles of patients' genetic and clinical risk factors.
Background: Comprehensive management of multimorbidity can significantly benefit from advanced health risk assessment tools that facilitate value-based interventions, allowing for the assessment and prediction of disease progression. Our study proposes a novel methodology, the Multimorbidity-Adjusted Disability Score (MADS), which integrates disease trajectory methodologies with advanced techniques for assessing interdependencies among concurrent diseases. This approach is designed to better assess the clinical burden of clusters of interrelated diseases and enhance our ability to anticipate disease progression, thereby potentially informing targeted preventive care interventions.
View Article and Find Full Text PDFIntroduction: Insomnia is a common symptom among patients with schizophrenia and schizoaffective disorder, negatively impacting symptom severity, functioning and well-being; however, it is rarely the direct focus of treatment. The main recommended treatment for insomnia is cognitive behavioural therapy (CBT-I). There is some evidence that CBT-I can also be used to treat insomnia in patients with schizophrenia, but only a few randomised controlled trials (RCTs) have been published.
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