Popper's Critical Rationalism as a Response to the Problem of Induction: Predictive Reasoning in the Early Stages of the Covid-19 Epidemic.

Unlabelled: The extent of harm and suffering caused by the coronavirus pandemic has prompted a debate about whether the epidemic could have been contained, had the gravity of the crisis been predicted earlier. In this paper, the philosophical debate on predictive reasoning is framed by Hume's problem of induction. Hume argued that it is rationally unjustified to move from the finite observations of past incidences to the predictions of future events.

Hospital treatment costs associated with incident complications in patients with type 2 diabetes-real-world study based on electronic patient information systems.

Background: Type 2 diabetes (T2D) and its complications cause a significant public health and economic challenge. To enable the optimal resource allocation across different prevention and treatment policies for the management of T2D-related complications, detailed cost estimates related to the complications of T2D are needed. Therefore, the objective of the study was to provide reliable and sufficiently detailed real-world estimates of costs associated with different T2D complications in a Finnish university hospital setting.

Flat-band superconductivity in periodically strained graphene: mean-field and Berezinskii-Kosterlitz-Thouless transition.

In the search of high-temperature superconductivity one option is to focus on increasing the density of electronic states. Here we study both the normal and-wave superconducting state properties of periodically strained graphene, which exhibits approximate flat bands with a high density of states, with the flatness tunable by the strain profile. We generalize earlier results regarding a one-dimensional harmonic strain to arbitrary periodic strain fields, and further extend the results by calculating the superfluid weight and the Berezinskii-Kosterlitz-Thouless (BKT) transition temperatureto determine the true transition point.

Heat shock protein 90 is downregulated in calcific aortic valve disease.

Background: Calcific aortic valve disease (CAVD) is an atheroinflammatory process; finally it leads to progressive calcification of the valve. There is no effective pharmacological treatment for CAVD and many of the underlying molecular mechanisms remain unknown. We conducted a proteomic study to reveal novel factors associated with CAVD.

Increased mesenchymal podoplanin expression is associated with calcification in aortic valves.

Background And Aim Of The Study: Calcific aortic valve disease (CAVD) is a progressive disease starting from mild valvular sclerosis and progressing to severe aortic stenosis (AS) with calcified valves. The origin of the calcification is proposed to be mesenchymal cells which have differentiated towards an osteoblastic phenotype. Podoplanin is a glycoprotein expressed in the endothelium of lymphatic vessels and in osteoblasts and osteocytes, mesenchymal cells, as well as in many carcinomas and aortic atherosclerotic lesions.