First Determination of the Spin-Parity of Ξ_{c}(3055)^{+,0} Baryons.

The Ξ_{b}^{0(-)}→Ξ_{c}(3055)^{+(0)}(→D^{+(0)}Λ)π^{-} decay chains are observed, and the spin-parity of Ξ_{c}(3055)^{+(0)} baryons is determined for the first time. The measurement is performed using proton-proton collision data at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 5.4  fb^{-1}, recorded by the LHCb experiment between 2016 and 2018.

A microglia clonal inflammatory disorder in Alzheimer's disease.

Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have investigated its role in neurodegenerative processes such as Alzheimer's disease (AD). Here, we report the selective enrichment of microglia clones carrying pathogenic variants, that are not present in neuronal, glia/stromal cells, or blood, from patients with AD in comparison to age-matched controls. Notably, microglia-specific AD-associated variants preferentially target the MAPK pathway, including recurrent CBL ring-domain mutations.

Taurine Attenuates Neuronal Ferroptosis by CSF-Derived Exosomes of GABABR Encephalitis Through GABABR/NF2/P-YAP Pathway.

GABAB receptor (GABABR) encephalitis represents a rare subtype of paraneoplastic limbic encephalitis (LE), characterized by persistent seizures and cognitive impairments. Nevertheless, the precise phenotype and underlying mechanisms of neuronal dysfunction associated with intrathecal lymphocytes in GABABR encephalitis remain inadequately understood. In the present study, we demonstrate that exosomes derived from the cerebrospinal fluid (CSF) of patients with GABABR encephalitis can induce neuronal ferroptosis, oxidative stress, iron accumulation, and lipid hyperoxidation in an in vitro model of anti-GABABR encephalitis.

Research progress on the anti-aging effect of polysaccharides of traditional Chinese medicine: Using Caenorhabditis elegans as an animal model.

With the growing elderly population and increasing incidence of various aging-related diseases, the scientific community is faced with an urgent challenge to identify natural anti-aging agents. Traditional Chinese medicine (TCM) polysaccharides have been proven to have good anti-aging activities. This article reviews the literature on the anti-aging pathways of traditional Chinese medicine polysaccharides applied to Caenorhabditis elegans models in the past decade.

Statistical Analysis of a Large-Scale Mental Health Survey Among Adolescents in Zigong, a Less-Developed City in China.

Objective: To investigate and report the psychosocial health status from a survey of adolescent populations in Zigong City, Sichuan Province, China, and analyze the overall condition of adolescent mental health in economically less-developed prefecture-level urban areas of China.

Methods: A survey on the mental health status of 95,455 adolescents in Zigong was conducted using eight scales: the Strengths and Difficulties Questionnaire for Students, the Pre-psychosis Questionnaire, the Patient Health Questionnaire, the Generalized Anxiety Disorder Scale, the Children's Revised Impact of Event Scale, the Pittsburgh Sleep Quality Index, the Internet Gaming Disorder Scale Short Form, and the Warwick-Edinburgh Mental Well-Being Scale. The survey assessed mental health across eight dimensions: emotional and behavioral problems, prodromal psychosis risk, depression, anxiety, stress reactions, sleep quality, internet addiction, and positive mental health.