Determinants of Caregiver Burden Among Spouses of Patients With Kidney Failure: A Qualitative Study.

Rationale & Objective: Spousal caregivers participate extensively in the care of patients with kidney failure. Although previous studies suggested that these caregivers experience a high burden, a comprehensive understanding of the determinants of this burden and strategies to alleviate it are needed. Therefore, this study sought to explore the contributing and alleviating determinants of burden in spousal caregivers of patients with kidney failure.

Informal caregiver burden in dialysis care and how it relates to patients' health-related quality of life and symptoms.

Background: Informal caregivers play a crucial role in dialysis care but may experience significant burden, potentially affecting both caregiver and patient outcomes. Research on caregiver burden and health-related quality of life (HRQoL) and the relation to patient-reported outcomes (PROs) is lacking. Therefore, we aimed to (i) describe informal caregivers' experienced burden and HRQoL and (ii) investigate how these are related to dialysis patients' HRQoL and symptoms.

Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks.

The brain's functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity, they also affect each other. The nature of such 'co-dependency' is difficult to disentangle experimentally, because multiple synapses must be monitored simultaneously.

A structurally precise mechanism links an epilepsy-associated potassium channel mutation to interneuron dysfunction.

De novo heterozygous variants in encoding the voltage-gated potassium (K) channel subunit Kv3.2 are a recently described cause of developmental and epileptic encephalopathy (DEE). A de novo variant in c.

Metabolically regulated spiking could serve neuronal energy homeostasis and protect from reactive oxygen species.

So-called spontaneous activity is a central hallmark of most nervous systems. Such non-causal firing is contrary to the tenet of spikes as a means of communication, and its purpose remains unclear. We propose that self-initiated firing can serve as a release valve to protect neurons from the toxic conditions arising in mitochondria from lower-than-baseline energy consumption.