Publications by authors named "T P Vahl"
Extracellular vesicles (EVs) are cell-secreted heterogeneous vesicles that play crucial roles in intercellular communication and disease pathogenesis. Due to their non-tumorigenicity, low immunogenicity, and therapeutic potential, EVs are increasingly used in cardiac repair as cell-free therapy. There exist multiple steps for the design of EV therapies, and each step offers many choices to tune EV properties.
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- The study investigates the use of off-label peripheral drug-coated balloons (P-DCB) for treating coronary in-stent restenosis (ISR) in patients, as dedicated drug-coated balloons are not available in the U.S.
- Data from 31 patients treated at a high-volume center showed that a significant percentage had recurrent ISR and high-grade symptoms, with most lesions found in native coronary arteries.
- Follow-up indicated that while no post-procedural heart attacks occurred, there was a notable recurrence rate of ISR, with only 44.7% of patients free from further issues at the time of follow-up.
Article Synopsis
- Limited data on strain changes after TAVI in patients with aortic regurgitation (AR) was explored in this study.
- Three patients experienced an initial decrease in global longitudinal strain (GLS) after TAVI, but showed significant improvement within the first year.
- The results suggest that GLS may be a better indicator than left ventricular end-diastolic diameter ratio for evaluating patients with severe volume overload.
Article Synopsis
- New postprocessing software enables 3D echocardiographic assessment of mitral annular and neo-left ventricular outflow tract dimensions in patients undergoing transcatheter mitral valve replacement.
- This study compares the accuracy of 3D echocardiographic analysis to that of baseline computed tomography in these measurements among 105 patients.
- Results show TEE underestimates mitral annular dimensions but gives comparable predictions for neo-LVOT area and peak gradients when compared to CT measurements.