Publications by authors named "T P Sheeran"
Background: Patients with inflammatory idiopathic myopathies (IIM) face elevated risks of osteoporosis and fragility fracture.
Aim: To evaluate current practice relating to bone health in adult patients with IIM in the United Kingdom and Hong Kong (HK).
Methods: Patients were identified from IIM patient lists.
Article Synopsis
- A study investigated the potential benefits of methotrexate, an antirheumatic drug, in treating knee osteoarthritis (KOA) pain through a multicenter, double-blind, placebo-controlled trial involving 207 participants.
- Participants were randomly assigned to receive either methotrexate or a placebo for 12 months while continuing their usual pain relief medications, with a primary focus on assessing average knee pain at 6 months.
- Results indicated that the methotrexate group experienced a significant decrease in knee pain compared to the placebo group, suggesting methotrexate may provide symptomatic relief for KOA.
Introduction: Youth tobacco use remains a critical public health concern, and childhood use of candy tobacco imitation products (CTIP) is associated with cigarette use among youth. However, no research has examined the full extent of CTIP available for purchase in the United States.
Aims And Methods: We conducted a content analysis of CTIP available on English-language, US-based websites.
Background: From early in the COVID-19 pandemic, evidence suggested a role for cytokine dysregulation and complement activation in severe disease. In the TACTIC-R trial, we evaluated the efficacy and safety of baricitinib, an inhibitor of Janus kinase 1 (JAK1) and JAK2, and ravulizumab, a monoclonal inhibitor of complement C5 activation, as an adjunct to standard of care for the treatment of adult patients hospitalised with COVID-19.
Methods: TACTIC-R was a phase 4, randomised, parallel-arm, open-label platform trial that was undertaken in the UK with urgent public health designation to assess the potential of repurposing immunosuppressants for the treatment of severe COVID-19, stratified by a risk score.