[Antonio Benivieni (1443-1502), Physician of the Renaissance].

Antonio di Paolo Benivieni (1443-1502) is one of the greatest physicians of Renaissance unfairly forgotten at the present time. Benivieni, in his major work of all his life «De abditis nonnullis ac mirandis morborum et sanationum causis», presents not only description of pathologic alterations (including the first in history description of carcinoma of pyloric part of stomach, mesenterial occlusion, fibrinogenous pericarditis) discovered at dissection but he tries to analyze and compare pathologic anatomic and clinical data. The treatise itself is the first in history pathologic anatomic work.

[Investigation of markers for myocardial remodeling during experimental hypobaric hypoxia in the correction with cytoflavin].

Unlabelled: The limited possibilities of determining myocardial morphological changes in the clinic make it necessary to investigate the effects of intermittent hypobaric hypoxia in an experiment setting.

Objective: To reveal the peculiarities of changes in the markers of myocardial remodeling in experimental hypobaric hypoxia.

Material And Methods: The investigation was conducted on 26 mature male Wistar rats weighing 220-310 g, which were divided into 3 groups: 1) 6 intact animals; 2) 10 rats that were exposed to 30-day simulated hypobaric hypoxia without correction; 3) 10 rats that were given once-daily intraperitoneal injections of cytoflavin solution at a rate of 0.

[The history of discovery of bulbourethral glands].

The article outlines the chronology of the discovery of the bulbourethral glands. Their first image appeared in 1600 in a collection of anatomical tables by Italian anatomist Hieronymus Fabricius of Acquapendente. In the scientific literature, they were first mentioned in one of the editions of "Journal des scavans" in 1684 as discovered by the French surgeon Jean Mry.

[MORPHOLOGICAL CHANGES IN RAT MYOCARDIUM EXPOSED TO HEMIC HYPOXIA AND TREATED WITH CYTOFLAVIN.].

This study was aimed at determining the influence of cytoflavin on the morphological features of contractile cardiomyocytes in female rats after gestation and in newborn rats exposed to hemic hypoxia induced by sodium nitrite (NaNO(2)). The experiment was performed on 28 three-month-old female Wistar albino rats and their offspring (24 seven-day-old newborns). Throughout pregnancy and during 7 days of suckling period, all animals divided into two groups were daily injected intraperitoneally with NaNO(2) at a dose of 5 mg/100 g body weight.

[Investigation of the antioxidant activity and cardioprotective effect of reamberin and cytoflavin in newborn rats exposed to chronic hemic hypoxia].

The authors analyzed the antioxidant activity of reamberin and cytoflavin and evaluated their cardioprotective effect, by investigating lipid peroxidation and oxidative modification of plasma proteins, as well as the ultrastructure of newborn rat cardiomyocytes under chronic hemic hypoxia induced by sodium nitrite. Reamberin and cytoflavin can reduce the manifestations of mitochondrial dysfunction and the degree of cardiomyocyte damage in the neonatal rats due to the antioxidant and membrane-protective properties of the drugs. Succinic acid in combination with the metabolic components of the drugs significantly inhibits lipid peroxidation, by improving the structure of membranes and the mitochondrial function of cardiomyocytes.