Publications by authors named "T P S Pinheiro"
Molecular test for screening malaria-infected blood donors to maximise recipient safety in Acre State, a Brazilian endemic area.
Mem Inst Oswaldo Cruz
December 2024
Background: Although blood transfusion is an essential therapeutic procedure, it can present risks, including transmitting infectious diseases, such as malaria. In Acre, the thick blood smear microscopic examination (TBS) is used to screen infected malaria blood donors. However, TBS has low sensitivity for detecting Plasmodium in situations of low parasitaemia, such as those presented by asymptomatic clinically healthy individuals.
View Article and Find Full Text PDFMetal complexes are emerging as promising alternatives to traditional platinum-based cancer treatments, offering reduced side effects. However, understanding their cellular uptake and distribution and quantifying their presence at the single cell level remains challenging. Advanced imaging techniques, including transmission electron microscopy, synchrotron radiation X-ray fluorescence, and energetic ion beam-based nuclear microscopy (scanning transmission ion microscopy, particle-induced X-ray emission, elastic backscattering spectrometry), allow detailed high-resolution visualization of structure and morphology, high sensitivity for elemental detection with quantification within single cells, and the construction of 3D models of metal distribution, positioning them as powerful tools for assessing the cellular uptake and compartmentalization of complexes.
View Article and Find Full Text PDFAn Objective Study to Establish Incidence of True Obstructive Sleep Apnoea (OSA) in Sleep Disordered Breathing in the Paediatric Age Group and Assessment of Benefit of Surgery (Tonsillectomy and Adenoidectomy) in Non Responders to Medical Treatment in Mild OSA.
Indian J Otolaryngol Head Neck Surg
October 2024
Article Synopsis
- Obstructive sleep apnea (OSA) involves partial or complete airway obstruction during sleep, leading to poor sleep quality and health issues, particularly in children.
- A study of 100 kids aged 4-12 assessed the severity of OSA and the effectiveness of surgical treatment, alongside comprehensive medical evaluations.
- Findings showed that medical treatments, including intranasal steroids, significantly improved symptoms of mild OSA, as reflected in better parental sleep questionnaires and reduced Apnoea/Hypopnoea Index scores.
Fatal case of imported visceral leishmaniasis in a dog caused by Leishmania infantum in French Guiana.
Vet Parasitol Reg Stud Reports
October 2024
Article Synopsis
- - The report discusses a case of fatal canine visceral leishmaniasis (VL) in a 2-year-old pug from Brazil, which was imported to French Guiana, a region not typically associated with this disease.
- - The dog initially showed a skin issue that healed, but later developed serious symptoms, leading to suspicion of VL, which was confirmed posthumously by testing for L. infantum.
- - This case highlights the rarity of canine VL in French Guiana and suggests a need for increased local surveillance to monitor potential transmission routes of the parasite.
Objective: To analyze the experiences of transgender women and travestis regarding the use of hormones for body changes without a medical prescription.
Methods: This is a cross-sectional, quantitative and qualitative study, using data from "TransOdara", which estimated the prevalence of Sexually Transmitted Infections in transgender women and travestis recruited through Respondent-Driven Sampling, between December 2019 and July 2021, in São Paulo, Campo Grande, Manaus, Porto Alegre, and Salvador, Brazil. The main outcome was: use of hormones without medical prescription and associated risk factors.