CD44/Integrin β1 Association Drives Fast Motility on Hyaluronic Acid Substrates.

In addition to proteins such as collagen (Col) and fibronectin, the extracellular matrix (ECM) is enriched with bulky proteoglycan molecules such as hyaluronic acid (HA). However, how ECM proteins and proteoglycans collectively regulate cellular processes has not been adequately explored. Here, we address this question by studying cytoskeletal and focal adhesion organization and dynamics on cells cultured on polyacrylamide hydrogels functionalized with Col, HA and a combination of Col and HA (Col/HA).

Accelerating Quantum Anharmonic Vibrational Calculations by Atom-Specific Hybrid Basis Set-Based Potential Energy Surface Approach.

The development of accurate yet fast quantum mechanical methods to calculate the anharmonic vibrational spectra of large molecules is one of the major goals of ongoing developments in this field. This study extensively explores and validates a hybrid electronic basis set approach for anharmonic vibrational calculations, where the molecule is segregated into different computational layers, and such layers are then treated with different levels of electronic basis sets. Following the system-bath model, the atoms corresponding to the active sites are treated in more accurate but computationally slower, large basis set and the rest of the atoms in less accurate but computationally faster, small basis set to construct the anharmonic hybrid potential energy surface (PES).

Unveiling Sociocultural Barriers to Breast Cancer Awareness Among the South Asian Population: Case Study of Bangladesh and West Bengal, India.

Background: Bangladesh and West Bengal, India, are 2 densely populated South Asian neighboring regions with many socioeconomic and cultural similarities. In dealing with breast cancer (BC)-related issues, statistics show that people from these regions are having similar problems and fates. According to the Global Cancer Statistics 2020 and 2012 reports, for BC (particularly female BC), the age-standardized incidence rate is approximately 22 to 25 per 100,000 people, and the age-standardized mortality rate is approximately 11 to 13 per 100,000 for these areas.

Insights into Interlayer Dislocation Augmented Zinc-Ion Storage Kinetics in MoS Nanosheets for Rocking-Chair Zinc-Ion Batteries with Ultralong Cycle-Life.

Increasing attention to sustainability and cost-effectiveness in energy storage sector has catalyzed the rise of rechargeable Zinc-ion batteries (ZIBs). However, finding replacement for limited cycle-life Zn-anode is a major challenge. Molybdenum disulfide (MoS), an insertion-type 2D layered material, has shown promising characteristics as a ZIB anode.

Synthesis of ethane from CO by a methyl transferase-inspired molecular catalyst.

Molecular catalysts with a single metal center are reported to reduce CO to a wide range of valuable single-carbon products like CO, HCOOH, CHOH, etc. However, these catalysts cannot reduce CO to two carbon products like ethane or ethylene and the ability to form C-C from CO remains mostly limited to heterogeneous material-based catalysts. We report a set of simple iron porphyrins with pendant thiol group can catalyze the reduction of CO to ethane (CH) with HO as the proton source with a Faradaic yield >40% the rest being CO.