Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade.

Peroxisome Proliferator Activated Receptor-gamma (PPAR-gamma) is a ligand-activated transcription factor belonging to the steroid receptor superfamily. It is a key regulator of adipogenic differentiation and glucose homeostasis, the ligands of which have also been demonstrated to induce differentiation in human breast, lung and colon cancer cell lines. In the present study, PPAR-gamma expression in cases of non-small cell lung carcinoma (NSCLC) was examined immunohistochemically and was correlated with tumor histological type and grade.

Ultrasonographic and histologic characteristics of symptom-free and symptomatic carotid plaque.

The purpose of the study was to determine the reliability of ultrasonography in assessing plaque pathology and to relate it to clinical symptoms. Ten symptom-free patients and 26 with symptomatic carotid plaques with a stenosis > 70%, as detected by arteriography, were assessed by duplex. The findings were compared with the clinical presentation and plaque pathology.