Publications by authors named "T P Mourikis"
The YAP-TEAD protein-protein interaction mediates YAP oncogenic functions downstream of the Hippo pathway. To date, available YAP-TEAD pharmacologic agents bind into the lipid pocket of TEAD, targeting the interaction indirectly via allosteric changes. However, the consequences of a direct pharmacological disruption of the interface between YAP and TEADs remain largely unexplored.
View Article and Find Full Text PDFYAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo pathway, while, in Uveal Melanoma (UM), YAP is activated in a Hippo-independent manner. To date, it is unclear if and how the different oncogenic lesions activating YAP impact its oncogenic program, which is particularly relevant for designing selective anti-cancer therapies.
View Article and Find Full Text PDFArticle Synopsis
- - High-dimensional cytometry is a cutting-edge method for monitoring the immune system in both healthy and diseased states, helping researchers discover new biological insights and disease biomarkers.
- - An R package called ImmunoCluster is introduced, which simplifies the analysis of complex cytometry data, enabling those without specialized computational skills to conduct immune profiling efficiently.
- - The ImmunoCluster package features a scalable framework for analyzing millions of cells, offering a structured protocol that includes data import, dimensionality reduction, clustering, and annotation, all within an accessible open-source environment.
Article Synopsis
- - Chromosomal instability in cancer leads to significant changes in chromosome number and structure, allowing for diverse somatic copy number alterations (SCNAs) that drive tumor evolution across various cancer types.
- - An analysis of over 1,400 tumor samples revealed that 37% showed parallel evolutionary events affecting the same key genes, with most recurrent chromosomal losses happening before the whole-genome doubling event.
- - Furthermore, certain SCNAs were found frequently in metastatic samples, indicating that chromosomal instability facilitates ongoing genetic changes that aid in the progression and diversity of tumors.