[Suppressor T-lymphocytes in continuously progressive juvenile schizophrenia].

The study of T lymphocyte suppressors in juvenile continuously progressive schizophrenia showed that the number of suppressor cells in patients was significantly decreased as compared to a group of mentally normal donors; 20.4% and 28.9% respectively.

[Classes of immunoglobulins responsible for serum antithymocyte activity in healthy subjects and mental pathology].

The antilymphocytic activity of the serum was examined in schizophrenic patients and in mentally healthy donors using the method of fluorescent antibodies. It was found that the antithymocytic activity of both the schizophreniacs and the healthy subjects was due to immunoglobulins G and M. The number of thymocytes showing fluorescence under the action of IgG was found to be approximately the same in both groups of the persons examined.

[Nature of antigens antibodies to which are detected in the serum of schizophrenic patients].

The study was conducted by the immune absorption method. The serum activity before and after absorption was studied with the cytotoxic test and the fluorescent antibody method. The studies demonstrated that antibodies, detected in the blood serum of patients and normals differ not only qualitatively but also quantitatively.

Antithymic immune factor in schizophrenia. A World Health Organization study.

Six WHO Collaborating Centre took part in the study of the antithymic activity of blood sera of patients suffering from schizophrenia. Blood serum specimens from 118 schizophrenic patients and 62 mentally healthy donors were investigated. Statistically significant differences between schizophrenic patients and the controls were found (p < 0.

[Antithymic factor in schizophrenia patients].

The paper concerns results of the studies, accomplished according to the WHO project within the framework of international collaboration in biological psychiatry. It was demonstrated that the blood sera of mental patients and normals possess antithymic activity. However there are statistically significant differences between the groups of patients and normals with regard to the level of sera antithymic activity (0,22 +/- 0,05 in normals and 0,47 +/- 0,04 in patients, p < 0,05).