Publications by authors named "T P Kam"
Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease.
J Extracell Vesicles
December 2024
The application of extracellular vesicles (EVs) as vehicles for anti-Parkinson's agents represents a significant advance, yet their clinical translation is hampered by challenges in efficient brain delivery and complex blood-brain barrier (BBB) targeting strategies. In this study, we engineered dopamine onto the surface of adipose-derived stem cell EVs (Dopa-EVs) utilizing a facile, two-step cross-linking approach. This engineering enhanced neuronal uptake of the EVs in primary neurons and neuroblastoma cells, a process shown to be competitively inhibited by dopamine pretreatment and dopamine receptor antibodies.
View Article and Find Full Text PDFα-Synuclein misfolds into pathological forms that lead to various neurodegenerative diseases known collectively as α-synucleinopathies. In this Review, we provide a comprehensive overview of pivotal advances in α-synuclein research. We examine structural features and physiological functions of α-synuclein and summarize current insights into key post-translational modifications, such as nitration, phosphorylation, ubiquitination, sumoylation and truncation, considering their contributions to neurodegeneration.
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- There is increased interest in using high-resolution T2 (hrT2) imaging for vestibular schwannoma (VS) and cochlea research, due to fewer side effects compared to contrast-enhanced T1 (ceT1) imaging.
- The challenge lies in a lack of annotated hrT2 data, which is crucial for developing effective segmentation models.
- The proposed solution is a target-aware unsupervised domain adaptation framework that focuses on the unique visual characteristics and sizes of these objects, improving image translation and preserving the quality of small structures.
Poly ADP-ribose signaling is dysregulated in Huntington disease.
Proc Natl Acad Sci U S A
October 2024
Article Synopsis
- Research indicates that DNA repair and mitochondrial health pathways are linked to HD, with study findings showing elevated DNA damage even before the disease manifests.
- Findings reveal that mutation carriers have lower levels of poly ADP-ribose (PAR) in their cerebrospinal fluid, and while wild-type HTT boosts PARP1 activity, the mutant form does not, highlighting potential pathways for developing early preventive treatments for HD.
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel bisindole alkaloid isolated from the Malayan plant . Herein, we report conofolidine's broad-spectrum anticancer activity together with that of three other bisindoles-conophylline, leucophyllidine, and bipleiophylline-against human-derived breast, colorectal, pancreatic, and lung carcinoma cell lines.
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