Publications by authors named "T P Jacobs"
Purpose: Motion management presents a significant challenge in thoracic stereotactic ablative radiotherapy (SABR). Currently, a 5.0 mm standard planning target volume (PTV) margin is widely used to ensure adequate dose to the tumor.
View Article and Find Full Text PDFThe NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3.
View Article and Find Full Text PDFMicroRNAs (miRNAs) control 60% of genes expressed in the human body, but their role in malaria pathogenesis is incompletely understood. Here, we demonstrate cell type-specific alterations to the miRNA profiles during the early response to malaria infection in brain and lung endothelial cells (ECs). In brain ECs, incubation with -infected red blood cells in the ring stage (iRBCs) most significantly affected endocytosis-related miRNAs and mRNAs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how brain network changes linked to Alzheimer's disease (AD) differ between those with amyloid-beta (A+) and normal elderly individuals (A-), using advanced deep learning on fMRI data.
- The researchers identified specific brain regions associated with cognitive functions like attention and memory, which were tied to biomarkers in cerebrospinal fluid (CSF) indicating levels of amyloid-beta and phosphorylated tau.
- Findings suggest these brain signatures link to various molecular pathways, helping to clarify the relationship between Alzheimer's pathology and cognitive decline.