Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- a subset analysis.

Objective: twice-daily flavocoxid, a cyclooxygenase and 5-lipoxygenase inhibitor with potent antioxidant activity of botanical origin, was evaluated for 12 weeks in a randomized, double-blind, active-comparator study against naproxen in 220 subjects with moderate-severe osteoarthritis (OA) of the knee. As previously reported, both groups noted a significant reduction in the signs and symptoms of OA with no detectable differences in efficacy between the groups when the entire intent-to-treat population was considered. This post-hoc analysis compares the efficacy of flavocoxid to naproxen in different subsets of patients, specifically those related to age, gender, and disease severity as reported at baseline for individual response parameters.

Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee.

Introduction: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes. This study was designed to compare the effectiveness and safety of flavocoxid to naproxen in subjects with moderate to severe osteoarthritis (OA) of the knee.

Methods: In this randomized, multicenter, double-blind study, 220 subjects were assigned to receive either flavocoxid (500 mg twice daily) or naproxen (500 mg twice daily) for 12 weeks.

[Comparative evaluation of clinical, cytological and cell culture methods of candida vulvovaginitis diagnosis].

98 patients with Candida vulvovaginitis (CVV) were examined clinically, cytologically and culturally. Three clinical forms of CVV were distinguished: acute and subacute (26 and 23 patients, respectively)--before treatment, and remission (49 patients)--after treatment. The clinical diagnosis of CVV before the treatment was confirmed cytologically and/or in cultures (87.

[Tuberculosis statistics by sectional data].

Analysis of sectional schedules and autopsy protocols for 1,061 persons who died of tuberculosis in Saint Petersburg in 1984-1991 has provided data on the age and sex distribution of the victims, the distribution of various types of tuberculosis as the underlying or concomitant disease, on the incidence and pattern of its complications, concurrent and competitive abnormalities and the causes of death. Comparison of previous results of the previous studies made regularly since 1981 has revealed stable and labile statistical parameters that characterize the evolution of tuberculosis as a disease, its pathomorphism in Saint Petersburg over the past century.