[Mexidol-induced modification of lipid metabolism in pancreatitis].

The chronic experiments on mongrel dogs with a model pancreatitis showed that mexidol decreases manifestations of the inflammatory process. The treatment with mexidol led to a decrease in the degree of lipid transformations in the initial stage of pancreatitis development, with normaliation of the lipid metabolism according to the liver and blood plasma characteristics. The membranoprotector effect of mexidol, manifested in normalization of the lipid spectrum, is probably related to inhibition of the lipid peroxidation (LPO) process and to a decrease in the activity of phospholipase A2.

[Effect of antioxidants on endotoxicosis in experimental peritonitis].

The chronic experiments on dogs with a peritonitis model showed that drugs possessing antioxidant properties (vitamin E, dimephosphon, xymedone) are capable of decreasing the inflammatory phenomena in abdominal cavity and decreasing the expression of endogenous intoxication, as manifested by a decrease in the plasma toxicity and the content of average-molecular-weight peptides and lipid peroxidation products. The most pronounced positive effect was observed for xymedone. A certain correlation between the effects of antioxidants upon endotoxicosis and free-radical lipid peroxidation reactions was established.