Association of serum vitamin D level and live birth rate in women undergoing frozen embryo transfer-a retrospective cohort study.

Purpose: To assess the association of serum vitamin D level and the live birth rate in women undergoing frozen embryo transfer (FET).

Methods: This is a retrospective cohort study involving 1489 infertile women who had frozen embryo transfer at two tertiary reproductive medicine centres from 2019 to 2021. Only the first frozen embryo transfer was included for women who had repeated transfers during the period.

Biomarkers.

Background: Increased uptake on Tau positron-emission tomography (PET) is sometimes observed in the absence of amyloid β accumulation. This A-T+ PET profile might represent primary age-related tauopathy (PART), an amyloid β-independent 3R/4R tauopathy observed in aging brains. Although A-T+ individuals have been shown to follow a different cognitive trajectory compared to A-T- and A+T+ individuals, it remains unknown how they differ in terms of plasma biomarkers.

Biomarkers.

Background: Tau burden has been found to be involved in brain atrophy during aging, especially in regions such as the parahippocampal gyrus. However, how tau levels at baseline are associated with trajectories of tau accumulation, cortical thinning and cognitive impairment remains poorly understood. The goal of this study was to assess tau rate of change in patients between baseline Tau+ and Tau- patients.

Biomarkers.

Background: This study aims to investigate the differential patterns of association in tau protein imaging across cortical regions using two distinct Tau imaging agents: [18F]MK6240 and [18F]Flortaucipir. The underlying hypothesis posits that variations in the properties of these tracers, such as affinity and off-target effects, influence the observed patterns of association in neuroimaging.

Method: To test this hypothesis, a comprehensive study was conducted involving 104 subjects part of the HEAD study at McGill University: 53 cognitively normal (CN), 19 with mild cognitive impairment (MCI), 9 with Alzheimer's Disease (AD) and 23 non-AD.

Biomarkers.

Background: Timely and non-invasive prediction of amyloid status are pivotal in Alzheimer's disease (AD) diagnostics. This research leverages T1 MRI images to predict amyloid positivity or negativity, offering an economical and less invasive alternative to amyloid PET scans. Using the comprehensive TRAID dataset from McGill University, the study evaluates a spectrum of cognitive conditions including AD, atypical AD, Cognitively Normal (CN), Mild Cognitive Impairment (MCI), MCI not due to AD, Suspected Non-Alzheimer's Pathophysiology (SNAP), and Vascular MCI (VMCI).