MCU-i4, a mitochondrial Ca uniporter modulator, induces breast cancer BT474 cell death by enhancing glycolysis, ATP production and reactive oxygen species (ROS) burst.

Objectives: Mitochondrial Ca uniporter (MCU) provides a Ca influx pathway from the cytosol into the mitochondrial matrix and a moderate mitochondrial Ca rise stimulates ATP production and cell growth. MCU is highly expressed in various cancer cells including breast cancer cells, thereby increasing the capacity of mitochondrial Ca uptake, ATP production, and cancer cell proliferation. The objective of this study was to examine MCU inhibition as an anti-cancer mechanism.

Occurrence, Transport, and Full-Scale Adsorptive Removal of PFAS in Electroplating Parks in China.

The electroplating industry is an important source of per- and polyfluoroalkyl substances (PFAS) contamination, but there is a lack of comprehensive studies on the occurrence, transport, and removal of PFAS in electroplating parks. In this study, we investigated typical electroplating parks in China and conducted the first full-scale removal of PFAS from chromium-plating wastewater using pore-enlarged granular activated carbon (GAC) and hydrophobic anion exchange resin (AER). The results showed that 6:2 fluorotelomer sulfonate (6:2 FTS) gradually replaced perfluorooctanesulfonate (PFOS) in China's electroplating industry.

In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor.

Human proteins repurposed as biologics for clinical use have been engineered through in vitro techniques that improve the affinity of the biologics for their ligands. However, the techniques do not select against properties, such as protease sensitivity or self-reactivity, that impair the biologics' clinical efficacy. Here we show that the B-cell receptors of primary murine B cells can be engineered to affinity mature in vivo the human CD4 domains of the HIV-1-entry inhibitor CD4 immunoadhesin (CD4-Ig).

Spatiotemporal evolution and transmission dynamics of Alpha and Delta SARS-CoV-2 variants contributing to sequential outbreaks in Cambodia during 2021.

Background: Tracking the emergence, introduction and spread of SARS-CoV-2 variants of concern are essential for informing public health strategies. In 2021, Cambodia faced two major epidemic waves of SARS-CoV-2 triggered by the successive rise of the Alpha and Delta variants.

Methods: Phylodynamic analysis of 1,163 complete SARS-CoV-2 genomes from Cambodia, along with global sequences, were conducted between February and September 2021 to infer viral introductions, molecular epidemiology and population dynamics.

The Summer North Atlantic Oscillation, Arctic sea ice, and Arctic jet Rossby wave forcing.

We use Coupled Model Intercomparison Project Phase 6 (CMIP6) coupled and Atmospheric Model Intercomparison Project (AMIP) climate models, dynamical analyses, and observations to investigate interactions between summer Arctic sea ice concentration (SIC) variations and the Summer North Atlantic Oscillation (SNAO). Observations suggest that SIC-SNAO relationships mainly come from the East Siberian to Arctic Canada (ESAC) region where a weak atmospheric jet stream exists in summer. Twelve CMIP6 models with the most realistic atmospheric climatologies over the North Atlantic and Europe agree well with reanalyses on relationships between SIC and Northern Hemisphere atmospheric circulation.