Publications by authors named "T Ottone"
Myeloid sarcoma (MS) is an extramedullary localization of immature granulocyte cells that can occur in association with acute myeloid leukemia (AML). Gastrointestinal involvement is relatively common in MS, but exclusive colonic localization is a rare occurrence. Here, we report on a 53-year-old male patient affected by AML developing a severe abdominal pain caused by intestinal perforation requiring surgical intervention.
View Article and Find Full Text PDFBackground: Arsenic trioxide (ATO) is an anticancer agent for treating acute promyelocytic leukemia (APL). However, 5-10% of patients fail to respond, developing relapsed/refractory disease. The aim of this study was to identify potential new therapeutic approaches for ATO-unresponsive APL by targeting the anti-apoptotic genes that contribute to drug resistance.
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- FLT3 mutations are common in adult acute myeloid leukemia (AML) and play a key role in risk assessment due to their significant impact on prognosis, especially internal tandem duplications (ITDs).
- Recent advancements have led to the approval of at least three targeted treatments for FLT3-mutated AML, with ongoing research into additional therapies.
- The introduction of FLT3 inhibitors has enhanced patient outcomes, and future studies are exploring combination therapies to further improve results in AML treatment.
Acute myeloid leukemia (AML) with inv(16) is typically associated with a favourable prognosis. However, up to 40 % of patients will eventually experience disease relapse. Herein, we dissected the genomic and transcriptomic profile of inv(16) AML to identify potential prognostic markers and therapeutic vulnerabilities.
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