Publications by authors named "T Orlikowsky"
GLUT1 deficiency prevents glucose uptake in T cells resulting in lower intracellular ATP generation and IFNy production.
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- This study assessed the effectiveness of a set of interventions aimed at lowering medication errors during parenteral drug preparation in a neonatal and pediatric intensive care unit (NICU/PICU).
- A clinical pharmacist and a pharmacy technician identified critical medication processes and introduced five key interventions, including improved drug labeling and centralized preparation for high-risk medications.
- Following these interventions, the overall error rate decreased significantly from 1.32% to 0.78%, demonstrating that the strategies implemented successfully enhanced medication safety in the NICU/PICU.
Background: In mechanically ventilated neonates, the arterial partial pressure of ( ) is an important indicator for the adequacy of ventilation settings. Determining the is commonly done using invasive blood gas analyses, which constitute risks for neonates and are typically only available infrequently. An accurate, reliable, and continuous estimation of is of high interest for medical staff, giving the possibility of a closer monitoring and faster reactions to changes.
View Article and Find Full Text PDFMore than 13 million children are born preterm annually. Prematurity-related mortality accounts for 0.9 million deaths worldwide.
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- Amphiregulin (AREG) is a key ligand for the epidermal growth factor receptor (EGFR) that affects monocyte-induced cell death and T-cell responses in peripheral blood.
- The study found that AREG reduces T-cell proliferation during stimulation and down-regulates costimulatory molecules on monocytes, indicating its role in modulating immune responses.
- Additionally, AREG influences T-cell polarization, leading to an increase in IL-17-producing T cells, while maintaining the regulatory T cell proportion.