Analysis of the Medication Persistence Rate for and Adherence to Oral 5-Aminosalicylic Acid Preparations in Japanese Patients with Ulcerative Colitis: Study Using a Nationwide Claims Database.

Introduction: 5-aminosalicylic acid (5-ASA) is the first-line drug for the treatment of mild-to-moderate ulcerative colitis (UC). Three oral sustained-release formulations are often used. However, no unified view of their actual use in routine medical practice has been presented to date.

The Largest Quasicrystalline Tiling with Dodecagonal Symmetry from a Single Pentablock Quarterpolymer of the ABCBD Type.

A quasicrystalline tiling pattern with tile size of . 60 nm has been discovered in the bulk state of a four-component pentablock polymer molecule of the type, where A, S, I, and P denote poly(4-vinylbenzyldimethylamine), polystyrene, polyisoprene, and poly(2-vinylpyridine), respectively. The polymer samples used were prepared by anionic polymerizations and have narrow molecular weight distribution.

Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells; a novel cyclooxygenase-2-inhibition-independent effect.

Nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive activity and may be suitable for treatment of colorectal cancer. A popular and potent NSAID, indomethacin, is known to cause serious side-effects, for this reason its therapeutic usefulness is limited. However, these side-effects are likely to be attributed to the additional effects of indomethacin besides its cyclooxygenase inhibition.

Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.

Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]-arachidonic acid uptake in HCA-7 human colon cancer cells.