Publications by authors named "T Omata"
Background: Hearing loss prevalence increases with age, affecting over 25% of the global population aged 60 years or older. The aim of the study was to investigate the association between the development of sensorineural hearing loss (SNHL) and the blood levels of nicotinamide adenine dinucleotide (NAD).
Methods: A single-center, observational study was conducted at Kawagoe Otology Institute in Japan.
Article Synopsis
- Short-chain enoyl-CoA hydratase is an important enzyme that helps break down certain fats and amino acids, and not having enough of it can lead to Leigh syndrome, a serious condition.
- A case was reported of a 6-month-old boy who showed symptoms like being sleepy and having trouble breathing, along with signs of severe ketosis, which means his body was producing too many ketones.
- Tests on his brain showed problems, and special genetic tests revealed he had changes in his genes that led to the enzyme deficiency; a diet low in valine might help manage this condition.
Article Synopsis
- AESD is a prevalent encephalopathy syndrome among Japanese children, and this report presents a unique case where MRI did not show typical abnormalities, but ASL indicated hyperperfusion.
- A 1-year-old boy experienced a consciousness disorder following prolonged seizures; initial brain MRI was normal, but ASL revealed hyperperfusion in specific brain areas later on.
- The study concludes that ASL could be a more effective method than DWI for identifying lesions in children suspected of having AESD, highlighting its importance in diagnosis.
Article Synopsis
- Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) can be hard to tell apart from long-lasting febrile seizures, especially in kids.
- A study looked at the effects of a special mix of vitamins and supplements, called a "mitochondrial cocktail," to see if it can help prevent AESD in children with prolonged seizures related to fever.
- The results showed that kids who received the mitochondrial cocktail had a much lower chance of developing AESD compared to those who didn't, suggesting that giving this mix early could be helpful in preventing the condition.
Article Synopsis
- Infantile traumatic brain injury (TBI) with a biphasic clinical course, known as TBIRD, is a newly identified type of TBI in infants, but its underlying mechanisms and outcomes are still not fully understood.
- A study involving ten patients aged 3-15 months compared MRS data of those diagnosed with TBIRD to those without, revealing significantly higher glutamine levels in TBIRD patients and decreased N-acetyl aspartate levels that correlated with worse neurological outcomes.
- The findings suggest that elevated glutamine may indicate the development of TBIRD and that N-acetyl aspartate levels could help predict the prognosis for these patients.