Publications by authors named "T Olea"
Clin Kidney J
September 2022
Article Synopsis
- C3 glomerulopathy is a rare kidney disease that affects how the complement system works, making it hard to predict individual patient outcomes.
- Researchers conducted a study involving 115 patients across 35 nephrology centers to develop a nomogram that forecasts long-term kidney survival using factors like estimated glomerular filtration rate (eGFR), proteinuria, and chronicity score from kidney biopsies.
- The final nomogram showed high accuracy (C-index of 0.860) in predicting kidney failure risk at 1, 2, 5, and 10 years, demonstrating reliable calibration between predicted and actual outcomes.
Nephrol Dial Transplant
June 2022
Article Synopsis
- This study investigates how changes in protein levels in urine (proteinuria) over time relate to kidney health in patients with complement component 3 (C3) glomerulopathy.
- Conducted across 35 nephrology departments in Spain, the research analyzed patient data from 1995 to 2020, focusing on the link between proteinuria trends and kidney failure risk.
- Findings reveal that higher proteinuria levels significantly increase the risk of kidney failure, while a reduction of 50% or more in proteinuria is associated with a decreased risk, highlighting proteinuria changes as useful indicators for predicting kidney outcomes.
Article Synopsis
- A study aimed to validate a previously proposed prognostic histologic index for C3 glomerulopathy (C3G) by analyzing kidney biopsy findings in a new patient cohort from Spain.
- The research included 111 patients from various nephrology departments, with assessments focusing on demographic data, clinical parameters, and specific C3G scoring systems.
- Results showed that 43% of patients developed kidney failure, with significant predictors identified, including eGFR, proteinuria, and specific histological features like tubular atrophy and interstitial fibrosis.
Clin J Am Soc Nephrol
September 2020
Article Synopsis
- - The study investigates C3 glomerulopathy, a kidney disease linked to abnormalities in the complement system, to identify factors influencing treatment outcomes with corticosteroids and mycophenolate mofetil (MMF).
- - Conducted across 35 nephrology departments in Spain, the research analyzed data from 97 patients diagnosed with C3 glomerulopathy or dense deposit disease to evaluate remission rates and kidney survival.
- - Results showed that treatment with corticosteroids plus MMF led to significantly better outcomes (79% remission; 14% kidney failure) compared to other treatments, especially in patients with autoantibody-mediated forms, while those with genetic variants had only partial remissions.
Clin J Am Soc Nephrol
August 2019
Article Synopsis
- The study investigates the increasing incidence of IgA nephropathy among older adults (aged ≥65) and analyzes various clinical aspects of the disease based on a cohort of 151 patients diagnosed between 1990 and 2015.
- Researchers observed a significant rise in diagnoses over the years, with common symptoms including asymptomatic urinary issues and acute kidney injury (AKI), particularly related to hematuria.
- The study found that age, serum creatinine levels, and kidney biopsy findings were linked to worse outcomes, while treatment with specific medications showed potential benefits for survival rates.
