Publications by authors named "T Okuma"

Article Synopsis
  • * Using mouse models, researchers found that renal injury activated the mineralocorticoid receptor (MR), which was linked to increased levels of HMGB1 and RAGE, and that blocking this pathway lessened kidney damage and inflammation.
  • * Results indicate that HMGB1 is a key factor in the development of AKI and its progression to CKD by activating the Rac1/MR pathway, suggesting potential therapeutic targets for preventing kidney injury.
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Objective: Surgical intervention is commonly necessary for craniosynostosis. One of the preoperative concerns revolves around the cerebral venous drainage pattern and its potential involvement during surgery. Although there have been reports regarding venous drainage patterns in syndromic craniosynostosis, studies of nonsyndromic cases have been rare.

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Cardiovascular diseases (CVDs) are a major cause of death in patients undergoing hemodialysis (HD). Blood pressure (BP) and uremic toxins are well-known risk factors for CVDs, which are influenced by diet. Dietary fiber supplementation in patients undergoing HD may reduce the risk of CVDs by improving lipid profiles and inflammatory status and lowering the levels of the uremic toxin indoxyl sulfate (IS).

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Interstitial lung abnormalities (ILAs) are immune checkpoint inhibitor (ICI)-related pneumonitis (ICI-P) risk factors. However, the relationship between imaging patterns and immunotherapy outcomes, and treatment strategies remain unclear in patients with non-small cell lung cancer (NSCLC) and ILAs. We retrospectively evaluated patients with ILAs-complicated NSCLC who received ICI therapy.

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