Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model.

Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but is associated with side effects. Topical drug administration effectively minimizes side effects. We aimed to investigate potential trends of the efficacy of topical delgocitinib administration in a mouse model.

Synthesis of functional enzymes involved in glutathione production during linear motility in boar sperm.

Sperm cells are highly susceptible to oxidative stress, which decreases their motility and fertility. However, glutathione (GSH) plays a critical role in protecting sperm cells from oxidative damage, a common byproduct of mitochondrial oxidative phosphorylation. On the other hand, GSH biosynthesis in sperm is limited by the availability of cysteine (Cys), which is inherently unstable and found at low concentrations in boar seminal plasma.

Visibility of Intracranial Perforating Arteries Using Ultra-High-Resolution Photon-Counting Detector Computed Tomography (CT) Angiography.

Photon-counting detector computed tomography (PCD-CT) offers energy-resolved CT data with enhanced resolution, reduced electronic noise, and improved tissue contrast. This study aimed to evaluate the visibility of intracranial perforating arteries on ultra-high-resolution (UHR) CT angiography (CTA) on PCD-CT. A retrospective analysis of intracranial UHR PCD-CTA was performed for 30 patients.

Novel Treatment of 3D-Printed Short-Carbon-Fiber-Reinforced Polyamide (3D-SCFRPA66) Using Homogeneous Low-Potential Electron Beam Irradiation (HLEBI) and Ductility Enhancement.

In short-carbon-fiber-reinforced polyamide 66 articles shaped by 3D printing (3D-SCFRPA66), the interfaces between printed layers are often susceptible to damage, and the composite is excessively brittle. Therefore, a novel treatment for 3D-printed short-carbon-fiber-reinforced polyamide (3D-SCFRPA66) using homogeneous low-potential electron beam irradiation (HLEBI) to enhance tensile properties was investigated. In 3D-SCFRPA66 samples, ductility was measured based on the following parameters: strain at tensile strength (corresponding to homogeneous deformation) () and resistance energy to homogeneous deformation, a measure of toughness (), which were both substantially increased.