Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP4.

In hypoxic pulmonary hypertension (PH), pulmonary vascular remodeling is characterized by the emergence of activated adventitial fibroblasts, leading to medial smooth muscle hyperplasia. Previous studies have suggested that CD26/dipeptidyl peptidase-4 (DPP4) plays a crucial role in the pathobiological processes in lung diseases. However, its role in pulmonary fibroblasts in hypoxic PH remains unknown.

From Headache to Altered Consciousness: Headache Attributed to Hypoxia and/or Hypercapnia in a Smoker With Undiagnosed Chronic Obstructive Pulmonary Disease.

We present the case of a 57-year-old male with a history of smoking, hypertension, dyslipidemia, and migraines who experienced a one-month history of dyspnea and headaches, followed by sudden-onset altered consciousness. Initial imaging ruled out cerebrovascular and infectious etiologies, and arterial blood gas analysis revealed severe hypercapnia and hypoxemia (partial pressure of arterial carbon dioxide: 117 mmHg, partial pressure of arterial oxygen: 111 mmHg under a 10 L/min oxygen mask). The patient's condition improved with mechanical ventilation, resulting in the resolution of both altered consciousness and headaches.

Hemoglobinopathy as a Rare Differential Disease for Low Oxygen Saturation by Pulse Oximetry: A Case Report and Literature Review.

Pulse oximetry is used to screen for respiratory failure in dyspnea patients. However, pulse oximetry can yield false-positive results in certain situations. Unstable hemoglobinopathy is a disease in which mutations in the globin-encoding gene result in abnormal globin chain production, causing low percutaneous oxygen saturation (SpO) levels due to changes in hemoglobin absorbance and oxygen affinity.

A case of early-stage type 3 gastric neuroendocrine tumor in the upper body of the stomach: is endoscopic resection feasible?

Although gastric neuroendocrine tumors (NETs) are uncommon compared with gastric carcinomas, the incidence of NETs has been recently increasing. Gastric NETs are classified into three subgroups, and among these, gastrin-independent sporadic type 3 gastric NETs have a poor prognosis because of frequent lymph node or distant metastasis. We experienced a case of an early-stage type 3 gastric NET associated with lymphovascular and submucosal invasion.

[Significance of Inflammatory/Nutritional Index in Pathological Stage Ⅱ-Ⅲ Colorectal Cancer].

The aim of this study was to evaluate the inflammatory/nutritional index in patients with colorectal cancer. A total of 600 patients with pStage Ⅱ-Ⅲ colorectal cancer who underwent radical resection at our hospital between January 2008 and September 2022 were retrospectively reviewed. Onodera's prognostic nutritional index(OPNI), CRP-to-albumin ratio, modified Glasgow prognostic score, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio were measured preoperatively.