Publications by authors named "T Ohmori"
Kidney organoids are connected to the host circulation and mature after transplantation. However, they are still immature compared to the adult kidneys, and their precise maturation stages remain unclear. By transplanting the mouse embryonic kidney as a model system for organoid transplantation, we report here the maturation defects of the graft, especially in the medulla.
View Article and Find Full Text PDFArticle Synopsis
- Carotegrast methyl (CGM) is a newly approved oral medication in Japan for treating moderately active ulcerative colitis (UC) in patients who don’t respond well to traditional treatments like 5-aminosalicylates.
- A study involving 14 Japanese patients showed that CGM led to significant endoscopic improvement in 64% of cases, with many experiencing reduced symptoms like diarrhea and abdominal pain after treatment.
- The study concluded that CGM appears to be a safe and effective option for inducing remission in patients with UC, with no reported serious side effects during the observation period.
Article Synopsis
- PC is a crucial plasma anticoagulant, and mutations in both alleles can lead to a serious condition called neonatal purpura fulminans.
- The study developed a genome editing approach using engineered activated protein C (APC) to treat congenital PC deficiency by expressing it in mouse liver through adeno-associated virus vectors and CRISPR/Cas9.
- Results showed that the engineered APC prolonged coagulation time, inhibited harmful thrombus formation, and improved the survival of PC-deficient mice, indicating its potential as a cure for this severe condition.
Article Synopsis
- * Diagnostic tests including echocardiography and Holter electrocardiography revealed a temporary high-grade atrioventricular block associated with the vomiting, leading to a diagnosis of situational syncope.
- * The cat improved with antiemetic treatment, but later died from chronic kidney disease about 3 years after the diagnosis, marking the first reported instance of situational syncope due to vomiting in a cat.
Article Synopsis
- - The study aimed to identify social determinants of health (SDOH) that contribute to health inequities experienced by Japanese patients with cardiovascular diseases (CVD).
- - An online survey of 2,083 CVD patients revealed high agreement on seven key SDOH factors, including employment, food insecurity, and poverty, which were linked to perceived health inequities.
- - Factors such as younger age, higher income, and education levels were associated with a greater perception of these health inequities, indicating that similar SDOH issues seen in Western countries also affect Japanese CVD patients.