Publications by authors named "T Ohkawara"
Novel germline STAT3 gain-of-function mutation causes autoimmune diseases and severe growth failure.
J Allergy Clin Immunol Glob
November 2024
Article Synopsis
- The study investigates a young boy with severe autoimmune conditions who was found to have a germline gain-of-function mutation in the STAT3 gene through whole-exome sequencing.* -
- Treatment with the targeted therapy tocilizumab led to a reduction in hospital stays and slowed the progression of pulmonary fibrosis, showing promise for managing his condition without increasing steroid use.* -
- The findings suggest that genetic testing and functional analysis of STAT3 mutations are important for diagnosing early-onset autoimmune diseases and for considering targeted treatment options.*
Lipolysis-stimulated lipoprotein receptor (LSR) is known as a lipoprotein receptor. LSR is expressed in various solid tumors, including epithelial ovarian, gastric, and colon cancers. High LSR expression is significantly associated with poor prognosis, but its role in cancer has not been fully elucidated.
View Article and Find Full Text PDFBackground/aim: Monoclonal antibodies (mAbs) that target tumor antigens have recently been developed. Their antitumor activity is mainly achieved through antibody-dependent cellular cytotoxicity (ADCC) via effector cells such as tumor-infiltrated macrophages and natural killer (NK) cells. CpG oligodeoxynucleotides (ODNs) have potent antitumor activity and are considered to increase the tumor infiltration of macrophages and NK cells; however, a completely solubilized novel CpG-schizophyllan (SPG) complex, K3-SPG, displays more potent antitumor activity.
View Article and Find Full Text PDFBackground: Epithelial ovarian cancer (EOC) is a lethal malignant tumor, for which new treatment options are urgently required. Lipolysis-stimulated lipoprotein receptor (LSR) is widely expressed in EOC, and it is associated with poor prognosis. In this study, we developed an antibody-drug conjugate (ADC) targeting LSR as a new therapeutic approach to EOC.
View Article and Find Full Text PDF