Publications by authors named "T Ohashi"
Anemia is a major clinical manifestation seen in myelodysplastic syndromes (MDS). Treatment options for anemia in low-risk MDS are limited. Especially, oral medication which is uniformly effective for anemia in low-risk MDS is required.
View Article and Find Full Text PDFBackground: Previously, we proposed that the immune-modified Glasgow Prognostic Score (imGPS), which adds the lymphocyte count to the mGPS, is helpful as a prognostic marker for patients with head and neck squamous cell carcinoma. In this study, we investigated the imGPS as a marker for the therapeutic effect of pembrolizumab in treating recurrent and metastatic head and neck cancer (RMHNC).
Methods: This study included RMHNC patients who were treated with pembrolizumab from December 2019 to April 2024.
Article Synopsis
- Fabry disease is a genetic disorder resulting from a deficiency in the enzyme α-galactosidase A, and early treatment options can improve outcomes, especially in cardiac cases.
- A study involving 56 Fabry disease patients and 58 healthy controls found that contractile function, measured by longitudinal strain (LS) using echocardiography, was significantly worse in Fabry patients without left ventricular (LV) hypertrophy.
- The findings indicate that early contractile dysfunction can be detected in Fabry disease patients even before LV hypertrophy occurs, highlighting the importance of using global LS and other LS metrics in monitoring the disease.
Purpose: A cyst-like structure near superior sagittal sinus (Arachnoid Cuff Exit Site cysts: ACES cysts) has been reported in MRI. The purpose of this study was to investigate the association between presence of ACES cysts and cognitive function, as assessed using mini-mental state examination (MMSE) scores.
Methods: We retrospectively analyzed patients who underwent head MRI for dementia screening.
Background: Gait retraining, through altering foot progression angle, has the potential to reduce pain and offload the medial tibiofemoral compartment in people with knee osteoarthritis. This pilot study aimed to evaluate the feasibility of toe-in and toe-out gait retraining on self-reported pain and physical function, and proxy measures of medial knee load, in individuals with medial knee osteoarthritis.
Methods: Twenty participants with symptomatic medial knee osteoarthritis were randomly allocated to receive either toe-in or toe-out gait retraining for six-weeks, consisting of weekly clinician-supervised sessions and ≥ 30 min of daily self-practice.