Publications by authors named "T Obadia"
Background: While invasive fusariosis and lomentosporiosis are known to be associated with fungemia, overall data on mold-related fungemia are limited, hampering early management. This study aimed to describe the epidemiology of mold-positive blood cultures.
Methods: Epidemiological and clinical data on mold-positive blood cultures from 2012 to 2022 were obtained from the RESSIF database.
Article Synopsis
- Mucormycosis, a severe fungal infection highlighted by the WHO, was studied in France from 2012 to 2022, revealing significant trends in epidemiology and mortality factors.
- Out of 550 cases, key underlying conditions included hematological malignancies (65.1%), with pulmonary infections most common (52.4%) and substantial seasonal variations suggesting more cases in autumn.
- The study linked the rise in PCR diagnostic methods to improved patient outcomes, highlighting that age, ICU diagnosis, and hematological malignancies increased mortality, while diagnosis after 2015 and surgical interventions decreased it.
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point toward membrane tension and bending rigidity as the minimal set of mechanical parameters determining the nucleation and maximal size of transendothelial cell macroaperture (TEM) tunnels induced by bacterial RhoA-targeting mART exotoxins. We report that cellular depletion of caveolin-1, the membrane-embedded building block of caveolae, and depletion of cavin-1, the master regulator of caveolae invaginations, increase the number of TEMs per cell.
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- The Great Mekong Subregion has seen significant reductions in malaria cases, yet certain populations, particularly forest workers and migrants, continue to contribute to ongoing transmission hotspots.
- The study involved tracking the movements of male forest goers over two 28-day periods by combining GPS data, questionnaires, and health exams to assess their exposure to malaria.
- Findings indicated that malaria risk was higher in villages with less forest cover, suggesting that proximity to forest does not necessarily increase malaria risk, and that there was a notable discrepancy between GPS tracking and self-reported movement data.
Article Synopsis
- - Over the past few decades, malaria cases in Cambodia have decreased significantly, leading to fragmented transmission in remote areas, prompting a study to examine the burden of Plasmodium infections near the forest regions in Mondulkiri.
- - The study involved 950 participants from 2018 to 2020, where blood samples were tested for Plasmodium infections and a risk analysis was conducted. It found that living in the forest greatly increased the risk of infection, particularly in adult males.
- - Results indicated that baseline serological status (whether participants tested positive or negative) was a strong predictor of future infections, stressing the need for targeted serological testing to effectively address malaria risks, especially in demographics living outside forest areas.