Publications by authors named "T OLARIU"
Development of Solid Nanosystem for Delivery of Chlorhexidine with Increased Antimicrobial Activity and Decreased Cytotoxicity: Characterization and In Vitro and In Ovo Toxicological Screening.
Molecules
January 2025
The evaluation of chlorhexidine-carrier nanosystems based on iron oxide magnetic nanoparticles (IOMNPs), has gained significant attention in recent years due to the unique properties of the magnetic nanoparticles (NPSs). Chlorhexidine (CHX), a well-established antimicrobial agent, has been widely used in medical applications, including oral hygiene and surgical antisepsis. This study aims to report an in vitro and in ovo toxicological screening of the synthesized CHX-NPS nanosystem, of the carrier matrix (maghemite NPSs) and of the drug to be delivered (CHX solution), by employing two types of cell lines-HaCaT immortalized human keratinocytes and JB6 Cl 41-5a murine epidermal cells.
View Article and Find Full Text PDFModern dentistry is turning towards natural sources to overcome the immunological, toxicological, aesthetic, and durability drawbacks of synthetic materials. Among the first biomaterials used as endosseous dental implants, mollusk shells also display unique features, such as high mechanical strength, superior toughness, hierarchical architecture, and layered, microporous structure. This review focusses on hydroxyapatite-a bioactive, osteoconductive, calcium-based material crucial for bone healing and regeneration.
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- * In a study of 17,273 urine samples, 130 cases tested positive for GBS, with a higher prevalence among women aged 25-34 years compared to younger women.
- * Antibiotic resistance testing revealed that GBS strains were sensitive to penicillin, ampicillin, and vancomycin, but showed high resistance rates to clindamycin and tetracycline, highlighting the need for careful antibiotic management.
Malaria is currently the most prevalent life-threatening infectious disease in the world. In this case report, we present a 44-year-old Caucasian woman with a low level of education and no significant past medical history who presented to the emergency room of the Emergency County Hospital of Arad, Romania, with a general affected state, a fever of 38.5 °C, chills, weakness, headache, muscle pain, nausea, icterus, and watery diarrheal stool.
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- Cancer patients are at a higher risk for severe COVID-19, and identifying specific biomarkers related to this risk could help target early treatment.
- A study analyzed plasma from 128 cancer patients with COVID-19 and found that lower levels of certain miRNAs (hsa-miR-150-5p and hsa-miR-93-5p) correlated with increased mortality, while hsa-miR-92b-3p linked to COVID-19 positivity.
- The research suggests that monitoring these miRNAs could serve as a potential blood biomarker for predicting COVID-19 severity in cancer patients, improving clinical outcomes.