Publications by authors named "T O Topcu"
Mandala as a New Intervention for Reducing Fear of Childbirth: A Randomized Controlled Trial.
J Midwifery Womens Health
December 2024
Introduction: Fear of childbirth is common in nulliparous women. More accessible and less costly interventions such as mandala are needed to reduce fear of childbirth. The purpose of this study was to test the efficacy of mandala coloring added to antenatal education to reduce fear of childbirth.
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- * The study included 36 patients, half of whom experienced primary resistance; response rates to IPI3 were 25%, with a notable 30% in those with primary resistance.
- * The findings suggest that IPI3 following low-dose IPI has significant clinical activity, emphasizing the importance of dosing strategies in managing melanoma treatment.
Brain metastases are common in advanced melanoma and cause death in >50% of patients. Until recently, median survival was only ∼4 months. Improved systemic treatment including immune checkpoint inhibitors and combinations of BRAF/MEK inhibitors, however, has significantly improved intracranial tumor response and survival.
View Article and Find Full Text PDFBackground: Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine carcinoma of the skin. In this study, we aimed to evaluate the clinicopathologic characteristics, treatment outcomes, and survival of MCC cases in Turkey.
Materials And Methods: The patients diagnosed with MCC between 1999 and 2018 at twenty different centers in Turkey were included in the study.
Objective: Studies have investigated expression status of galectin-3 (Gal-3), but very little is known about the importance of circulating Gal-3 in patients with breast cancer (BC). The purpose of the study was to investigate the clinical significance and potential diagnostic value of plasma Gal-3 levels in patients with BC.
Materials And Methods: Fifty-two patients with BC and 35 age-matched healthy controls were enrolled.