Publications by authors named "T O Paulson"
Mathematical modeling of somatic evolution, a process impacting both host cells and microbial communities in the human body, can capture important dynamics driving carcinogenesis. Here we considered models for esophageal adenocarcinoma (EAC), a cancer that has dramatically increased in incidence over the past few decades in Western populations, with high case fatality rates due to late-stage diagnoses. Despite advancements in genomic analyses of the precursor Barrett's esophagus (BE), prevention of late-stage EAC remains a significant clinical challenge.
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- * A new algorithm called OM2BFB was developed to effectively detect BFB amplifications using optical genome maps, achieving high accuracy and recall in identifying these events across various cancer models.
- * BFB amplification tends to occur more in certain cancers (like cervical and lung) and results in lower variability in gene expression compared to ecDNA amplifications, which may indicate different patterns of treatment resistance and offer
Significance of Crypt Atypia in Barrett's Esophagus: A Clinical, Molecular, and Outcome Study.
Clin Gastroenterol Hepatol
April 2024
Background & Aims: The aim of this study was to characterize baseline morphologic features of crypts in nondysplastic Barrett's esophagus and correlate them with DNA content abnormalities and risk of progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).
Methods: The morphologic features of nondysplastic crypts in baseline biopsy specimens from 212 BE patients (2956 biopsy specimens) were graded histologically using a 4-point scale (crypt atypia levels, 0-3). DNA content abnormalities were detected using flow cytometry.
Article Synopsis
- - The study aimed to evaluate how well Ratings of Perceived Exertion (RPE) can be used to guide a 4-week handcycling training program for untrained adults.
- - Thirty participants were split into three groups: one trained using RPE, another using power output, and a control group. Various measurements like oxygen uptake, heart rate, and feelings during the sessions were taken.
- - Results showed no significant differences in performance metrics between the RPE and power output groups, indicating that RPE is an effective tool for prescribing moderate to vigorous handcycling workouts in rehabilitation settings.