Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has imposed substantial challenges on our society due to the COVID-19 pandemic. This virus relies heavily on its surface glycoprotein (S-glycoprotein) to facilitate attachment, fusion, and entry into host cells. While the nucleoprotein (N) in the ribonucleoprotein core binds to the viral RNA genome.

An innovation bootcamp model for developing youth-led HIV self-testing delivery strategies in Nigeria: post-designathon capacity building.

Introduction: Many designathons, hackathons, and similar participatory events suffer from minimal training and support after the events. Responding to this need, we organized a health innovation bootcamp: an intensive, team-based apprenticeship training with research and entrepreneurial rigor among young people in Nigeria to develop HIV self-testing (HIVST) delivery strategies for Nigerian youth. The purpose of this paper was to describe an innovation bootcamp that aimed to develop HIVST delivery strategies for Nigerian youth.

Genetic Analysis of the Impact of Heat Stress on Fertility Traits in Dairy Cows in the Netherlands.

This study aimed to use Temperature-Humidity Index (THI) as an indicator for assessing heat stress conditions for fertility traits in the Holstein dairy cattle breed in the Netherlands. Data from artificial insemination and calving events of 416,814 first-parity cows from the Netherlands were used, considering different THI definitions based on different numbers of days before and after artificial insemination events. To achieve our aim, we investigated first, at population level, the relationship between different THI definitions and 4 fertility traits: conception rate, interval calving to first insemination, interval first to last insemination, and calving interval.

Prognostic Utility of Modified 5-Item Frailty Index on the Outcomes of Spine Surgeries: A Systematic Review and Meta-Analysis.

Background: Frailty refers to a state of weakness that can arise due to age or illnesses, and frailty predisposes individuals to several adverse health outcomes. This has been postulated to prognosticate the outcome of various surgeries, including surgeries for various spine conditions; however, no meta-analysis has validated this finding.

Methods: We conducted a systematic review and meta-analysis to investigate the prognostic utility of frailty for the outcome of spine surgeries.

Effect of market participation on the food and nutrition security status of the rural smallholder farmers: the case of Limpopo and Mpumalanga provinces, South Africa.

Introduction: Hunger and malnutrition remain serious issues in developing countries, particularly in rural regions. Increased market participation of smallholder farmers can result in improved livelihood and nutrition outcomes. However, smallholder farmers encounter several obstacles that hinder their ability to participate in the market.