Publications by authors named "T O Isola"
Lutein protection against doxorubicin-induced liver damage in rats is associated with inhibition of oxido-inflammatory stress and modulation of Beclin-1/mTOR activities.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Article Synopsis
- Doxorubicin (DOX) can cause significant liver damage in both humans and animals, but the impact of lutein, a natural carotenoid, on liver toxicity caused by DOX is not well understood.
- This study aimed to investigate how lutein protects against doxorubicin-induced liver damage in male Wistar rats through various treatment groups, including a control group and groups receiving either DOX, lutein, or both.
- Results indicated that lutein significantly reduced harmful enzyme levels and oxidative stress markers while enhancing protective enzymes, restoring liver structure, and modulating key cellular pathways involved in inflammation and autophagy.
Background: The high prevalence of the risk factors of head and neck cancer (HNC) amongst senior secondary (high) school students in Nigeria is an issue of serious public health concern. Therefore, this study aimed to assess the knowledge of HNC among them.
Methods: This cross-sectional study surveyed 2,530 senior secondary school students in Nigeria, assessed their knowledge of HNC, using a self-administered questionnaire.
Background: Cigarette and alcohol use are the most common causes of noncommunicable diseases. Studies related to cigarette and alcohol use among Nigerian adolescents have shown increases in the habits and require urgent intervention. Nationally representative data is needed to develop effective national policies and interventions, but this is lacking.
View Article and Find Full Text PDFBACKGROUND Kidney transplantation is reported to save costs compared to maintenance dialysis. We analyzed the current actual costs of kidney transplantation compared to dialysis, and analyzed risk factors for higher costs after transplantation. MATERIAL AND METHODS Altogether, 338 kidney transplant recipients between 2009 and 2014 were included in this study.
View Article and Find Full Text PDFAntimicrobials are used to maintain good health and productivity of food animals. Misuse of antibiotics in livestock contributes to development of antimicrobial resistance, an emerging One Health issue. This study assessed pastoralists' knowledge and practices regarding antimicrobial usage, explore pathways for resistant pathogens emergence and associated social drivers for antimicrobial misuse in pastoral herds of North-central Nigeria.
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