[Reactions between protease inhibitors in blood plasma and collagen].

The interaction of three macroglobulins and three serpines, as well as inter-alpha-trypsin inhibitor (ITI) with alpha 1- and alpha 2-chains of collagen I which were immobilized on nitrocellulose. All seven proteinase inhibitors were shown to have a certain affinity for collagen. The binding of alpha 2-macroglobulin and gestation-associated protein A with collagen chains is largely determined by the conformational state of these macrophages.

[The generation of active forms of oxygen by mouse macrophages: the effect of the genotype, immunocytokines and infection].

In this work the effect of the natural complex of cytokines on the generation of active forms of oxygen (AFO) by mouse peritoneal macrophage in different in vivo and in vitro systems were studied. Intact mice of various strains were found to have differences in the AFO production of their macrophages: BALB/c (H-2d) > CBA (H-2k) > C57BL/6 (H-2b), as well as in the degree of the prestimulation of the macrophage oxygen metabolism with the complex of cytokines BALB/c > CBA. The in vivo and in vitro infection of macrophages of mice, oppositely reacting to Leishmania donovani, led to the gradual suppression of the capacity of macrophages for AFO generation.