Publications by authors named "T O'Toole"
Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association may be influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic load cross-sectionally and at a lag of four years, stratified by level of effort-reward imbalance. The sample consisted of respondents from the English Longitudinal Study of Ageing (ELSA) who were in employment with hair cortisol measurements at baseline (wave 6), and allostatic load markers at baseline and follow-up (wave 8; n=411; 64 % female).
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- The study investigates the effectiveness of axatilimab, a CSF1R-blocking antibody, for treating chronic graft-versus-host disease (GVHD) in patients post-hematopoietic stem-cell transplantation.
- In a phase 2 trial involving 241 participants, different doses of axatilimab were tested, with overall response rates of 74%, 67%, and 50% across three dose groups.
- Alongside substantial improvement in GVHD symptoms measured by patient-reported outcomes, the most frequent side effects were temporary lab abnormalities linked to the treatment.
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- The study investigates the connection between lipoprotein (a) [Lp(a)] levels and the risk of obstructive coronary artery disease (CAD) and high-risk plaque (HRP) in patients with stable chest pain.
- Researchers analyzed data from the PROMISE Trial, finding that elevated Lp(a) (≥50 mg/100 ml) correlates with greater chances of having stenosis (≥50% and ≥70%) in coronary arteries, regardless of low-density lipoprotein cholesterol (LDL-C) levels.
- However, elevated Lp(a) was not linked to the presence of high-risk plaque when accounting for obstructive CAD, suggesting its role in CAD risk is more significant than in plaque features.
Carnosine is an endogenous dipeptide that buffers intracellular pH and quenches toxic products of lipid peroxidation. Used as a dietary supplement, it also supports exercise endurance. However, the accumulation and distribution of carnosine after supplementation has not been rigorously evaluated.
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