Publications by authors named "T Numakura"
An indocyanine green fluorescence-guided operation for diagnosing and treating pleuroperitoneal communication.
Multimed Man Cardiothorac Surg
May 2024
Pleuroperitoneal communication occurs when ascites moves from the abdominal cavity to the pleural cavity via a diaphragmatic fistula. Managing large pleural fluid volumes is challenging, often requiring an operation. Identifying small diaphragmatic fistulas during the operation can be problematic, but ensuring their detection improves outcomes.
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- A report discusses a 43-year-old Japanese woman diagnosed with Hermansky-Pudlak syndrome (HPS), exhibiting respiratory issues like cough and difficulty breathing.
- High-resolution CT scans showed abnormal lung patterns, and her diagnosis was confirmed through a prolonged bleeding time and a mutation in the HPS1 gene.
- Treatment with pirfenidone led to improvements in her respiratory symptoms, suggesting that it may be a viable option for patients with HPS awaiting lung transplantation.
Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. However, subpopulations of AMs participating in chronic inflammation have been poorly characterized. We previously reported that Siglec-1 expression on AMs, which is important for bacteria engulfment, was decreased in COPD.
View Article and Find Full Text PDFBackground: 27-Hydroxycholesterol (27-HC) derived from sterol 27-hydroxylase (CYP27A1) has pro-inflammatory biological activity and is associated with oxidative stress and chronic inflammation in COPD. However, the role of regulation of CYP27A1- 27-HC axis in asthma is unclear. This study aimed to elucidate the contribution of the axis to the pathophysiology of asthma.
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