Publications by authors named "T Nosaka"
Human parainfluenza virus type 2 (hPIV2), one of the causative agents of infantile common cold, is a non-segmented negative-sense RNA virus with a robust gene expression system. It infects recurrently throughout human life without causing severe disease. Because hPIV2 has a viral envelope that can carry ectopic proteins, we developed a non-propagative RNA/protein-carrying vector BC-PIV by deleting the F gene from hPIV2.
View Article and Find Full Text PDF[Gastrointestinal mucosal injury caused by cancer chemotherapy including immune checkpoint inhibitors].
Nihon Shokakibyo Gakkai Zasshi
October 2024
Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal lung disease characterized by tissue scarring and declining lung function. The promoter polymorphism rs35705950, a significant genetic predisposition for IPF, paradoxically associates with better survival and slower disease progression than other IPF genotypes. This study investigates the potential paradoxical protective effects of this variant in lung fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- Circulating tumor cells (CTCs) are important noninvasive biomarkers that help indicate how well cancer treatments are working and can predict patient prognosis, specifically in hepatocellular carcinoma (HCC) patients undergoing Atezo-Bev therapy.
- The research involved collecting blood samples from healthy individuals and HCC patients, isolating CTCs using a specific depletion cocktail, and analyzing them for certain cellular markers.
- Results showed that changes in CTC counts and specific markers (like CD90 and EpCAM) correlated with treatment responses and overall survival, suggesting these markers could help predict outcomes for HCC patients on Atezo-Bev therapy.