Publications by authors named "T Noponen"
Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus.
Mov Disord Clin Pract
December 2024
Background: While previous imaging studies have generally shown normal striatal dopamine transporter (DAT) binding in essential tremor (ET), emerging evidence suggests a partial dopaminergic mechanism in this condition and an epidemiological link between ET and Parkinson's disease (PD). This link seems particularly meaningful in ET patients with additional neurological signs, such as slowness of movements, rigidity, or rest tremor (ET+).
Objectives: To investigate the potential dopaminergic pathophysiology of ET+ and to compare it to PD.
Article Synopsis
- The study analyzed external dose-rate signals from remote dose-rate meters (DRMs) in differentiated thyroid cancer (DTC) patients to understand the excretion of radioactive iodine (RAI) post-treatment.
- It involved 110 patients monitored during hospitalization, revealing that the median effective half-life (T) of iodine was 12.60 hours and that higher BMI, lower GFR, and diabetes were linked to longer T values.
- The research concluded that remote DRMs are effective for monitoring radiation levels and can help optimize hospital isolation periods, enhancing both patient comfort and staff efficiency.
Article Synopsis
- Voiding cystourethrography (VCUG) is widely used to diagnose vesicoureteral reflux (VUR) but has high radiation exposure; direct radionuclide cystography (DRC) was created to address this issue.
- A study involving 156 children assessed the effectiveness of DRC compared to VCUG and found that DRC identified VUR in 35.3% of patients, while VCUG found it in 61.5%.
- Despite DRC being intended as a lower-radiation option, it actually resulted in higher radiation exposure and additional costs, raising questions about its use in screening for VUR.
Objective: This study was undertaken to investigate the effects of dietary caffeine intake on striatal dopamine function and clinical symptoms in Parkinson disease in a cross-sectional and longitudinal setting.
Methods: One hundred sixty-three early Parkinson disease patients and 40 healthy controls were investigated with [I]FP-CIT single photon emission computed tomography, and striatal dopamine transporter binding was evaluated in association with the level of daily coffee consumption and clinical measures. After a median interval of 6.
Background: Gastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry per se but might be associated with lower left striatal dopamine transporter (DAT) binding. The purpose of this study was to further investigate if specific gastrointestinal symptoms associate with monoamine transporter changes in specific striatal or extrastriatal areas.
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