Publications by authors named "T Noma"
Background: The association between tumor-infiltrating lymphocytes and tumor immunity has long been recognized. Among T-cell types, CD45RO-positive memory T cells (CD45RO) are reported to correlate with survival in several cancer types, but clinical evidence is lacking in esophageal squamous cell carcinoma (ESCC).
Methods: In surgical specimens from 162 preoperatively untreated patients, immunohistochemistry for CD45RO was performed to evaluate the density of CD45RO in the tumor core (CT) and invasive margin (IM) using an auto-count method.
Article Synopsis
- * Results showed that ADC values were significantly lower in advanced gallbladder cancer compared to benign and non-advanced tumors, suggesting a correlation between low ADC and increased cancer severity.
- * Additionally, lower ADC values predicted worse disease-free survival and overall survival, making them potential indicators for assessing tumor aggressiveness in gallbladder cancer.
Article Synopsis
- Pathological cardiac hypertrophy leads to reduced heart contractility due to an energy deficit from metabolic issues, especially in glucose metabolism.
- This study examines D-Allose, a rare sugar, for its potential to restore metabolic balance and reverse cardiac hypertrophy by treating isolated neonatal rat heart cells with it while stimulating them with phenylephrine.
- Results show D-Allose significantly reduced cardiomyocyte size and remodeling markers, decreased intracellular glucose levels, and inhibited glycolysis, also demonstrating effectiveness in mice with ISO-induced cardiac hypertrophy by reducing related markers with minimal impact on heart wall thickness.